Doing Double Duty

Science's STKE  19 Oct 2004:
Vol. 2004, Issue 255, pp. tw379
DOI: 10.1126/stke.2552004tw379

Gene expression in eukaryotes is normally believed to be controlled by transcriptional regulators that activate the expression of genes encoding structural proteins and enzymes. Hall et al. have used proteome chips and chromatin immunoprecipitation to identify a metabolic enzyme, Arg 5,6, that binds to DNA and directly regulates gene expression. Arg 5,6 not only catalyzes two steps of arginine biosynthesis in yeast but also directly binds to several genes. Knockouts of this enzyme result in changes in transcript levels of nuclear and mitochondrial target genes.

D. A. Hall, H. Zhu, X. Zhu, T. Royce, M. Gerstein, M. Snyder, Regulation of gene expression by a metabolic enzyme. Science 306, 482-484 (2004). [Abstract] [Full Text]