Editorial Guide

Focus Issue—The Dynamics of Gene Expression

Science's STKE  26 Oct 2004:
Vol. 2004, Issue 256, pp. eg11
DOI: 10.1126/stke.2562004eg11

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It is gene expression that defines a cell's identity. Science, Science's Science of Aging Knowledge Environment (SAGE KE), and Science's STKE focus attention on the highly dynamic nature of gene expression. Mechanisms governing selective gene expression in multigene families, as well as those by which cis- and trans-acting factors contribute to regulation of gene expression, are topics under discussion. In addition, new methodologies allow researchers to gain insight into gene expression at the level of single cells and provide a glimpse at the real-time interactions among proteins and DNA.

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