Controlling Ovulation

Science's STKE  14 Dec 2004:
Vol. 2004, Issue 263, pp. tw449
DOI: 10.1126/stke.2632004tw449

In the mammalian ovary, oocytes are maintained in meiotic arrest until the female ovulation cycle directs meiosis to resume just prior to ovulation. A Gs-linked receptor in the mouse oocyte membrane acts as a regulator of the transition between meiotic prophase and metaphase. Mehlmann et al. now identify GPR3 as the oocyte receptor required for the maintenance of prophase arrest.

L. M. Mehlmann, Y. Saeki, S. Tanaka, T. J. Brennan, A. V. Evsikov, F. L. Pendola, B. B. Knowles, J. J. Eppig, L. A. Jaffe, The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science 306, 1947-1950 (2004). [Abstract] [Full Text]