Editors' ChoiceImmunology

Calcium Channels in T Lymphocytes

Science's STKE  11 Jan 2005:
Vol. 2005, Issue 266, pp. tw22
DOI: 10.1126/stke.2662005tw22

Calcium represents a critical signaling mediator in a number of biological systems, including in excitable cells such as neurons and in lymphocytes of the immune system. However, the identity of channels that mediate calcium entry in lymphocytes has been unclear. Badou et al. (see Perspective by Winslow and Crabtree) find that T cells express two forms of voltage-gated calcium channel (Cav) that are required for mediating activation signals critical for normal T cell functions. Cav activity was increased directly by T cell receptor stimulation.

A. Badou, S. Basavappa, R. Desai, Y.-Q. Peng, D. Matza, W. Z. Mehal, L. K. Kaczmarek, E. L. Boulpaep, R. A. Flavell, Requirement of voltage-gated calcium channel β4 subunit for T lymphocyte functions. Science 307, 117-121 (2005). [Abstract] [Full Text]

M. M. Winslow, G. R. Crabtree, Decoding calcium signaling. Science 307, 56-57 (2005). [Summary] [Full Text]