Teaching Resource

A Model for Fast-Track Exocytosis of Synaptic Vesicles

Science's STKE  18 Jan 2005:
Vol. 2005, Issue 267, pp. tr2
DOI: 10.1126/stke.2672005tr2


The animation illustrates one model for "kiss-and-run" or fast-track release of neurotransmitter through a calcium-triggered transient pore formed between the synaptic vesicle and plasma membrane. The vesicles remain attached to the plasma membrane throughout the cycle. The animation illustrates a role for SNARE proteins and dynamin in the formation and closure of the pore. The animation would be useful in both neurobiology courses, but also any cell biology course that explores calcium-regulated secretion events.