Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance

Science's STKE  25 Jan 2005:
Vol. 2005, Issue 268, pp. pe4
DOI: 10.1126/stke.2682005pe4

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S6K1, like other serine and threonine kinases activated by insulin (such as mTOR and PKCζ), has recently been shown to participate in negative feedback mechanisms aimed at terminating insulin signaling through IRS (insulin receptor substrate) phosphorylation. Such homeostatic mechanisms can also be activated by excess nutrients or inducers of insulin resistance (such as fatty acids and proinflammatory cytokines) to produce an insulin-resistant state that often leads to the development of diabetes. Identification of the specific kinases involved in such insulin resistance pathways can help lead to the rational design of novel therapeutic agents for treating insulin resistance and type 2 diabetes.

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