Editors' ChoiceCell Cycle

A Matter of Timing?

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Science's STKE  08 Feb 2005:
Vol. 2005, Issue 270, pp. tw59
DOI: 10.1126/stke.2702005tw59

Understanding how genes function within an organism requires an evaluation of temporal as well as physical interactions. De Lichtenberg et al. have combined confidence-scored protein-protein interaction data with microarray data to provide a detailed view of cell cycle biology in yeast. The approach was used to make predictions about gene function. Almost all cell cycle complexes contained both subunits that showed a dynamic as well as those that had an unchanging pattern of expression. The dynamic subunits were the targets of cyclin-dependent phosphorylation, and it was their expression that was associated with the time at which the complex functioned.

U. de Lichtenberg, L. J. Jensen, S. Brunak, P. Bork, Dynamic complex formation during the yeast cell cycle. Science 307, 724-727 (2005). [Abstract] [Full Text]