Teaching Resource

Protein Domains that Interact with Receptor Tyrosine Kinases: Structural Aspects

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Science's STKE  08 Mar 2005:
Vol. 2005, Issue 274, pp. tr9
DOI: 10.1126/stke.2742005tr9

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This Teaching Resource provides lecture notes and slides for a class covering insights gained from structural analysis of the regulation of receptor tyrosine kinases and is part of the course "Cell Signaling Systems: A Course for Graduate Students." The lecture begins with an overview of the many protein domains thus far implicated in cell signaling and then describes in detail the phosphotyrosine-binding domain (PTB). The application of structural information to rational drug design by targeting protein interaction domains is also covered.

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