The Right Stuff for Wing Formation

Science's STKE  22 Mar 2005:
Vol. 2005, Issue 276, pp. tw109
DOI: 10.1126/stke.2762005tw109

Animal organs and appendages are composed of cells with different morphologies. For example, the Drosophila wing primordium displays cells that are squamous, cuboidal, or columnar. What are their molecular determinants for this cell variation? Gibson and Perrimon examine this question by screening flies with defects in epithelial cell morphogenesis in the wing. Mutation of a signaling receptor produced a wing defect in which cells are extruded from the epithelial surface. Contrary to earlier work that implicated this signaling pathway in cell survival, it appears that the signaling pathway is instead involved in epithelial organization and that any subsequent cell death is a secondary effect. Similar conclusions are reached by Shen and Dahmann.

M. C. Gibson, N. Perrimon, Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science 307, 1785-1789 (2005). [Abstract] [Full Text]

J. Shen, C. Dahmann, Extrusion of cells with inappropriate Dpp signaling from Drosophila wing disc epithelia. Science 307, 1789-1790 (2005). [Abstract] [Full Text]