Editors' ChoiceImmunology

A New View of an Old Receptor

Science's STKE  12 Apr 2005:
Vol. 2005, Issue 279, pp. tw137
DOI: 10.1126/stke.2792005tw137

γδ T cells represent a distinct lineage of T cells that undertake a range of specific immune functions. However, compared with their αβ T cell counterparts, the mode of antigen recognition by these T cells is still relatively poorly understood (see the Perspective by Garboczi). By resolving a 3.4 angstrom structure of the complex between a specific mouse γδ T cell receptor (TCR) and its nonclassical class I major histocompatibility complex ligand, Adams et al. have generated a new model of γδ T cell recognition, which has features of both innate immune receptor recognition and adaptive recognition through recombination of germline segments. Shin et al. arrive at similar conclusions from a survey of TCR usage at the single-cell level, which leads them to suggest that γδ T cells focus on a relatively narrow range of antigenic ligands.

D. N. Garboczi, "D" is not for diversity. Science 308, 209-210 (2005). [Summary] [Full Text]

E. J. Adams, Y.-H. Chien, K. C. Garcia, Structure of a γδ T cell receptor in complex with the nonclassical MHC T22. Science 308, 227-231 (2005). [Abstract] [Full Text]

S. Shin, R. El-Diwany, S. Schaffert, E. J. Adams, K. C. Garcia, P. Pereira, Y.-H. Chien, Antigen recognition determinants of γδ T cell receptors. Science 308, 252-255 (2005). [Abstract] [Full Text]