Editors' ChoicePhysiology

Round-the-Clock Metabolism

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Science's STKE  17 May 2005:
Vol. 2005, Issue 284, pp. tw192
DOI: 10.1126/stke.2842005tw192

The behavior of most organisms is organized around a 24-hour cycle. One of the key molecular regulators of this circadian rhythmicity is a transcription factor called CLOCK. Mice carrying a mutation in the Clock gene show profound disturbances in circadian behavior. Turek et al. now show that these Clock mutant mice also overeat, become overweight, and develop features of metabolic syndrome, including elevated serum levels of glucose and lipids. The metabolic disturbances were accompanied by alterations in the expression of neuropeptides implicated in appetite control and energy balance.

F. W. Turek, C. Joshu, A. Kohsaka, E. Lin, G. Ivanova, E. McDearmon, A. Laposky, S. Losee-Olson, A. Easton, D. R. Jensen, R. H. Eckel, J. S. Takahashi, J. Bass, Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308, 1043-1045 (2005). [Abstract] [Full Text]