Editors' ChoiceMicrobiology

Membrane Engineering

Science's STKE  24 May 2005:
Vol. 2005, Issue 285, pp. tw200
DOI: 10.1126/stke.2852005tw200

The intracellular pathogen Salmonella enterica resides in a vacuole from which it translocates effector proteins into the host cell. These bacterial effectors manipulate eukaryotic functions. SifA is a key Salmonella effector protein, and sifA mutants are highly attenuated in virulence in mice. Boucrot et al. now describe how Salmonella uses secreted effectors to negatively regulate the binding of the microtubule-associated kinesin motor onto the bacterial vacuole. SifA targets a host protein, SKIP, that down-regulates the recruitment of kinesin. In this manner, Salmonella controls the kinesin activity associated with its vacuole membrane and in turn the dynamics of membrane exchange.

E. Boucrot, T. Henry, J.-P. Borg, J.-P. Gorvel, S. Méresse, The intracellular fate of Salmonella depends on the recruitment of kinesin. Science 308, 1174-1178 (2005). [Abstract] [Full Text]