Human Papillomaviruses and Cell Signaling

See allHide authors and affiliations

Science's STKE  14 Jun 2005:
Vol. 2005, Issue 288, pp. pe29
DOI: 10.1126/stke.2882005pe29

You are currently viewing the abstract.

View Full Text


Human papillomaviruses cause cancer of the stratified epithelium, and the incidence of infection with these viruses in the genital tract is high. The alterations in the biology of normal epithelial cells that lead to malignancy are a consequence of the activity of certain viral proteins, whose function is to create an environment conducive to the replication of the viral genome through inhibition of epithelial cell differentiation and stimulation of proliferation.

View Full Text