Review

Histone Deacetylases as Transcriptional Activators? Role Reversal in Inducible Gene Regulation

Science Signaling  09 Aug 2005:
Vol. 2005, Issue 296, pp. re11
DOI: 10.1126/stke.2962005re11

You are currently viewing the abstract.

View Full Text

Log in


Abstract

Histone deacetylation enzymes have often been associated with the suppression of eukaryotic gene transcription. In contrast, recent studies of inducible gene regulation indicate that protein deacetylation can also be required as a transcriptional activation signal. The concept of protein deacetylation as a requirement for transcription activation seems to contradict earlier conclusions about the function of deacetylation in gene suppression. However, in the context of a more global interpretation, these opposing effects of deacetylation imply its dynamic role in the overall control of gene expression. The exact requirement for deacetylation differs among promoters, depending on their specific architecture and regulation scenario.

View Full Text