Editors' ChoiceCOMPUTATIONAL BIOLOGY

Network Analysis of Cell Regulation

STKE  16 Aug 2005:
Vol. 2005, Issue 297, pp. tw303
DOI: 10.1126/stke.2972005tw303

Fuller understanding of cellular regulation requires analysis of the interactions of multiple signaling pathways in the complex networks that control cellular functions. Ma'ayan et al. analyze the network properties of 545 components that undergo 1259 interactions underlying signaling and cell regulation in hippocampal neurons. The presence of regulatory motifs and other characteristics begin to reveal how cells may process information to allow, for example, transient or stable changes in cell function.

A. Ma'ayan, S. L. Jenkins,S. Neves, A. Hasseldine, E. Grace, B. Dubin-Thaler, N. J. Eungdamrong, G. Weng, P. T. Ram, J. J. Rice, A. Kershenbaum, G. A. Stolovitzky, R. D. Blitzer, R. Iyengar, Formation of regulatory patterns during signal propagation in a mammalian cellular network. Science 309, 1078-1083 (2005). [Abstract] [Full Text]