Teaching Resource

A Model for Local Regulation of Translation Near Active Synapses

Science's STKE  06 Sep 2005:
Vol. 2005, Issue 300, pp. tr25
DOI: 10.1126/stke.3002005tr25

Abstract

Synaptic plasticity results in enduring changes in synaptic function. Localized protein synthesis is part of this process. This animation shows how a dynamic macromolecular structure, the RNA granule, may allow localized translation of proteins at the site of active synapses and thereby serve as a key element contributing to changes in protein production leading to synaptic plasticity. This animation would be useful in teaching a neurobiology or neuroscience course, where it could be used to illustrate mechanisms for activity-dependent protein translation, or in a biochemistry course or a molecular or cellular biology course, where it could be used to illustrate mechanisms governing regulation of protein translation.