Genes and Waves

Science's STKE  11 Oct 2005:
Vol. 2005, Issue 305, pp. tw360
DOI: 10.1126/stke.3052005tw360

Slow electroencephalogram oscillations, or delta waves, represent one of the most important aspects of sleep and its regulation because they determine the depth of sleep, sleep consolidation, and sleep quality. Delta oscillations are also a direct measure of the need for sleep, and they are tightly regulated during development and aging. Maret et al. identified and functionally characterized a gene that codes for a vitamin A-activated ligand-dependent transcription factor, retinoic acid receptor beta (Rarb). This gene regulates slow-wave oscillations during sleep.

S. Maret, P. Franken, Y. Dauvilliers, N. B. Ghyselinck, P. Chambon, M. Tafti, Retinoic acid signaling affects cortical synchrony during sleep. Science 310, 111-113 (2005). [Abstract] [Full Text]