Editors' ChoiceNeurobiology

From Post- to Presynaptic Sites

Science's STKE  08 Nov 2005:
Vol. 2005, Issue 309, pp. tw396
DOI: 10.1126/stke.3092005tw396

Postsynaptic Ca2+ signals are somehow transduced into alterations in presynaptic function during enhanced synaptic activity. Yoshihara et al. show that in the Drosophila embryonic neuromuscular junction, miniature endplate potential induction by presynaptic stimulation is blocked by postsynaptic Ca2+ chelation or genetic ablation of synaptotagmin 4 (Syt 4). This blockage can be rescued by postsynaptically targeted "knockin" of Syt 4. Similarly, the reduced amplitude of endplate potentials in Syt 4-deficient mutants can be rescued by postsynaptic rescue of Syt 4. Postsynaptic Syt 4 thus up-regulates transmitter release.

M. Yoshihara, B. Adolfsen, K. T. Galle, J. T. Littleton, Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth. Science 310, 858-863 (2005). [Abstract] [Full Text]