Expedient Cytokine Trafficking

Science's STKE  06 Dec 2005:
Vol. 2005, Issue 313, pp. tw438
DOI: 10.1126/stke.3132005tw438

Phagosomes are formed when cells such as macrophages engulf relatively large particles, like bacteria, from the external milieu. The source of membrane involved in the formation of the phagosome and the ability of other organelles to fuse with the phagosome is a topic of recent controversy. Murray et al. describe a fundamental and clever adaptation of phagosomal membrane trafficking in macrophages, whereby recycling endosomes fuse with the newly forming phagosome to create the site for release of tumor necrosis factor--a proinflammatory cytokine involved in innate immunity.

R. Z. Murray, J. G. Kay, D. G. Sangermani, J. L. Stow, A role for the phagosome in cytokine secretion. Science 310, 1492-1495 (2005). [Abstract] [Full Text]