Cell Division

Keeping Survivin on Target

Science's STKE  06 Dec 2005:
Vol. 2005, Issue 313, pp. tw440
DOI: 10.1126/stke.3132005tw440

Many proteins are involved in the orchestration of the events required for the successful completion of mitosis. Vong et al. (see the Perspective by Earnshaw) searched for proteins that interact with survivin, a protein that functions in the regulation of mitosis and accumulates on condensing chromosomes at the centromeres and later on the spindle. A deubiquitinating enzyme known as hFAM was identified that appears to control localization of survivin and its association with other proteins. Survivin was coupled to ubiquitin through Lys63 linkages, a modification that influences protein-protein interactions, and this modification was necessary for proper binding of survivin to centromeres. Preventing ubiquitination by mutating Lys63 disrupted chromosome alignments and mitotic progression. Thus, enzymes regulating protein ubiquitination appear to have key regulatory roles in controlling the dynamic protein interactions required for proper execution of mitosis.

Q. P. Vong, K. Cao, H. Y. Li, P. A. Iglesias, Y. Zheng, Chromosome alignment and segregation regulated by ubiquitination of survivin. Science 310, 1499-1504 (2005). [Abstract] [Full Text]

W. C. Earnshaw, Keeping survivin nimble at centromeres in mitosis. Science 310, 1443-1444 (2005). [Summary] [Full Text]