Regulation of Voltage-Gated Ca2+ Channels by Calmodulin

Correction for Sci. STKE 2006(318):er1

Sci. STKE, 20 December 2005
Vol. 2005, Issue 315, p. re15
DOI: 10.1126/stke.3152005re15

Regulation of Voltage-Gated Ca2+ Channels by Calmodulin

  1. D. Brent Halling,
  2. Paula Aracena-Parks, and
  3. Susan L. Hamilton*
  1. Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
  1. *Corresponding author. E-mail: susanh{at}


The length of time that a voltage-dependent channel stays open can have a profound impact on the functional consequences of its opening. Together, Ca2+ and the Ca2+-binding protein calmodulin regulate the closing (Ca2+-dependent inactivation) and facilitate the opening (Ca2+-dependent facilitation) of voltage-gated Ca2+ channels. This review describes the features of calmodulin and its binding sites on voltage-gated Ca2+ channels that are likely to contribute to its ability to drive these opposing effects on channel activity.


D. B. Halling, P. Aracena-Parks, and S. L. Hamilton, Regulation of Voltage-Gated Ca2+ Channels by Calmodulin. Sci. STKE 2005, re15 (2005).

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