Linking NO Production and Prostaglandin Synthesis in Inflammation

Science's STKE  03 Jan 2006:
Vol. 2006, Issue 316, pp. tw467
DOI: 10.1126/stke.3162006tw467

Principal inflammatory responses in mammals include the induction of nitric oxide and prostaglandin synthesis in cells of the immune system. Kim et al. report that the enzymes that produce these molecules, nitric oxide synthase and cyclooxygenase-2, respectively, interact in macrophage cells. Nitric oxide synthase delivers NO to cyclooxygenase-2. This modification of cycooxygenase-2 by nitric oxide, known as S-nitrosylation, activates the enzyme. This synergism between the two systems may help in the design of potential novel anti-inflammatory drugs.

S. F. Kim, D. A. Huri, S. H. Snyder, Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science 310, 1966-1970 (2005). [Abstract] [Full Text]