Editors' ChoiceNeuroscience

Depression, Serotonin, and p11

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Science's STKE  10 Jan 2006:
Vol. 2006, Issue 317, pp. tw475
DOI: 10.1126/stke.3172006tw475

Serotonin is an important modulator in a large number of physiological and pathological brain states. Among the many different serotonin receptors, the 5-HT1B receptor plays a crucial role in regulating serotonin neurotransmission. Svenningsson et al. (see the Perspective by Sharp) investigated the role of a protein, p11, which appears to interact with 5-HT1B receptors, in depression and antidepressant treatment. 5-HT1B receptor function depended on p11 expression, and p11 levels were low in depressive states in animal models, transgenic overexpression and knockout lines, and human postmortem brains from depressed patients. In contrast, p11 levels were increased by antidepressant drugs and electroconvulsive treatment.

P. Svenningsson, K. Chergui, I. Rachleff, M. Flajolet, X. Zhang, M. El Yacoubi, J.-M. Vaugeois, G. G. Nomikos, P. Greengard, Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311, 77-80 (2006). [Abstract] [Full Text]

T. Sharp, A new molecule to brighten the mood. Science 311, 45-46 (2006). [Summary] [Full Text]