Phosphatidylserine and Signal Transduction: Who Needs Whom?

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Science's STKE  17 Jan 2006:
Vol. 2006, Issue 318, pp. pe3
DOI: 10.1126/stke.3182006pe3

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The plasma membrane, long considered a simple barrier between the extracellular and intracellular compartments, is now thought to play a pivotal role in many physiological processes that regulate the communication of cells with their environment. On one hand, the plasma membrane directly participates in intracellular signaling; on the other hand, changes in membrane structure contribute to the transcellular transfer of biological information. Among the membrane constituents, phosphatidylserine is a major actor implicated in these effects. Evidence now exists for a role for phosphatidylserine redistribution in modulating the activities of several membrane proteins during signaling in nonapoptotic T lymphocytes.

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