Rho, Rho, Rho Your Vaccinia

Science's STKE  24 Jan 2006:
Vol. 2006, Issue 319, pp. tw33
DOI: 10.1126/stke.3192006tw33

Viruses subvert a variety of host cell mechanisms during infection, replication, and dissemination. Valderrama et al. now describe how vaccinia virus promotes cellular motility by interfering with the activity of RhoA, a small guanosine triphosphase-binding protein involved in intracellular signaling, which particularly affects the actin cytoskeleton. A conserved vaccinia protein, F11L, directly interacts with RhoA, mimicking one of its endogenous substrates, ROCK, and inducing cellular motility. The induced motility is likely to facilitate the spread of the virus within tissues.

F. Valderrama, J. V. Cordeiro, S. Schleich, F. Frischknecht, M. Way, Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 311, 377-381 (2006). [Abstract] [Full Text]