Editors' ChoiceNeuroscience

Neurotransmitters and Higher Cognitive Functions

Science's STKE  14 Feb 2006:
Vol. 2006, Issue 322, pp. tw66
DOI: 10.1126/stke.3222006tw66

The activity of the human prefrontal cortex is modulated by ascending neurotransmitter systems. However, the differential modulation of cognition by distinct neurochemical systems in man has yet to be elucidated. Chamberlain et al. demonstrate in healthy human volunteers a double dissociation for involvement of noradrenaline and serotonin in two cognitive functions that are critically implicated in everyday behavioral regulation and in the manifestation and treatment of psychiatric illnesses.

S. R. Chamberlain, U. Müller, A. D. Blackwell, L. Clark, T. W. Robbins, B. J. Sahakian, Neurochemical modulation of response inhibition and probabilistic learning in humans. Science 311, 861-863 (2006). [Abstract] [Full Text]