Perspective

Neuregulin-1 and Myelination

Science's STKE  07 Mar 2006:
Vol. 2006, Issue 325, pp. pe11
DOI: 10.1126/stke.3252006pe11

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Abstract

The trigger for the process of myelin formation during neural development has long been a mystery. Recent studies suggest that this trigger is the growth factor neuregulin-1, expressed on the surface of axons, which signals through ErbB2 and ErbB3 receptors expressed on the surface of myelin-forming glia.

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