Extending Genetic Interaction Maps

Science's STKE  14 Mar 2006:
Vol. 2006, Issue 326, pp. tw96
DOI: 10.1126/stke.3262006tw96

Although there are elegant interaction maps available for yeast and Drosophila, it will become more difficult to find complete, high-quality data for higher organisms. Zhong and Sternberg (see the Perspective by Eddy) have developed a computational approach to cross-species data integration and have used it to generate a map of Caenorhabditis elegans genetic interactions. To test the robustness of their predictions, RNA interference analysis was used to verify novel interactors predicted for let-60 and itr-1.

W. Zhong, P. W. Sternberg, Genome-wide prediction of C. elegans genetic interactions. Science 311, 1481-1484 (2006). [Abstract] [Full Text]

S. R. Eddy, Total information awareness for worm genetics. Science 311, 1381-1382 (2006). [Summary] [Full Text]