Editors' ChoiceWnt signaling

Endocytosis and Developmental Patterning

Science's STKE  16 May 2006:
Vol. 2006, Issue 335, pp. tw161
DOI: 10.1126/stke.3352006tw161

During animal patterning in development, morphogens, such as Wnt, form gradients that control local developmental responses. While searching for factors involved in Caenorhabditis elegans larval cell migration, Coudreuse et al. found a role for components of the conserved endocytic retromer complex. The retromer complex is required in cells that produce the Wnt ortholog EGL-20 and is needed to establish the EGL-20 concentration gradient, as well as for long-range signaling. Experiments with mammalian cell lines and Xenopus suggest a conserved function for the retromer complex in Wnt signaling, possibly by recycling the Wnt cargo receptor from the endosome to the Golgi.

D. Y. M. Coudreuse, G. Roël, M. C. Betist, O. Destrée, H. C. Korswagen, Wnt gradient formation requires retromer function in Wnt-producing cells. Science 312, 921-924 (2006). [Abstract] [Full Text]