Editors' ChoiceCalcium

CRACing Calcium Channels

Science's STKE  30 May 2006:
Vol. 2006, Issue 337, pp. tw184
DOI: 10.1126/stke.3372006tw184

Calcium release-activated calcium (CRAC) channels mediate influx of calcium across the plasma membrane when intracellular stores of calcium are depleted, an important event in receptor-stimulated calcium signaling in many cells. Vig et al. moved the search for the molecular identity of the CRAC channel one step closer by completing a high-throughput RNA interference screen for gene products required for CRAC channel function in Drosophila. Two membrane proteins, CRAC modulators 1 and 2 (CRACM1 and CRACM2), could be part of the CRAC channel itself or part of the regulatory machinery that controls it.

M. Vig, C. Peinelt, A. Beck, D. L. Koomoa, D. Rabah, M. Koblan-Huberson, S. Kraft, H. Turner, A. Fleig, R. Penner, J.-P. Kinet, CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 312, 1220-1223 (2006). [Abstract] [Full Text]