Perspective

Receptors as Microprocessors: Pharmacological Nuance on Metabotropic Glutamate Receptors 1α

Science's STKE  03 Jul 2006:
Vol. 2006, Issue 342, pp. pe29
DOI: 10.1126/stke.3422006pe29

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Abstract

G protein–coupled receptors have revealed themselves to be complex information-processing units that may be exploited for subtle therapeutic signaling effects. Thus, ligands may not only turn receptors on and off, but may also select from their repertoire of signaling effects to further refine drug response.

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