Editors' ChoiceDevelopment

The Well-Dressed Fly

Science's STKE  11 Jul 2006:
Vol. 2006, Issue 343, pp. tw232
DOI: 10.1126/stke.3432006tw232

Drosophila melanogaster sports a set of forewings and a small pair of serially homologous structures, termed halteres, that help provide balance during flight. Crickmore and Mann used genetic analyses to examine the variation in size control between the wing and haltere during development. Ultrabithorax (Ubx), a homeotic selector gene, controls the size of the haltere primordium and, subsequently, the haltere itself, by restricting the expression and mobility of the morphogen, Decapentaplegic (Dpp), via the Dpp receptor, thickveins. Thus, selector genes can regulate organ size by regulating both growth factors and their receptors.

M. A. Crickmore, R. S. Mann, Hox control of organ size by regulation of morphogen production and mobility. Science 313, 63-68 (2006). [Abstract] [Full Text]

D. L. Stern, Morphing into shape. Science 313, 50-51 (2006). [Summary] [Full Text]