Editors' ChoiceCell Biology

Nailing Down the Effects of Arginylation

Science's STKE  18 Jul 2006:
Vol. 2006, Issue 344, pp. tw242
DOI: 10.1126/stke.3442006tw242

Arginylation is a posttranslational modification critical for embryonic development, but the protein targets and molecular effects of arginylation are largely unknown. Karakozova et al. show the regulation of a single target protein by arginylation with effects on the molecular and cellular level. β-actin, an abundant, essential intracellular protein, is arginylated in vivo, and this modification regulates actin polymerization, cell motility, and lamella formation in motile cells.

M. Karakozova, M. Kozak, C. C. L. Wong, A. O. Bailey, J. R. Yates III, A. Mogilner, H. Zebroski, A. Kashina, Arginylation of β-actin regulates actin cytoskeleton and cell motility. Science 313, 192-196 (2006). [Abstract] [Full Text]

J. C. Bulinski, Actin discrimination. Science 313, 180-181 (2006). [Summary] [Full Text]