Systems Biology of AGC Kinases in Fungi

See allHide authors and affiliations

Science's STKE  12 Sep 2006:
Vol. 2006, Issue 352, pp. re9
DOI: 10.1126/stke.3522006re9

You are currently viewing the gloss.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


This STKE Review discusses the evidence that Sch9 is the yeast Saccharomyces cerevesiae homolog of mammalian protein kinase B. Protein kinase B and Sch9 are members of the AGC family of protein kinases, which are involved in diverse cellular functions, including nutrient-sensitive signaling that affects cell survival, cell size, cell cycle progression, and cellular response to stress. With 3 figures, 1 table, and 55 citations, this review provides a discussion of the methods for investigating AGC kinase function, with special emphasis on the challenges presented by the essential nature of these enzymes and their functional redundancy. There is also a discussion of how yeast cells can be used to study aging and longevity, with a description of the evidence for a role for Sch9 in aging and nutrient-sensitive processes.