Editors' ChoicePhysiology

Caveolin and Liver Regeneration

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Science's STKE  19 Sep 2006:
Vol. 2006, Issue 353, pp. tw321
DOI: 10.1126/stke.3532006tw321

Caveolin is a key component of caveolae, cell surface invaginations involved in the internalization of a variety of signaling molecules and the uptake of certain viruses. Surprisingly enough, when caveolin knockout mice were generated a few years ago, they appeared to be healthy. Fernández et al. have now examined these mice in more detail and discovered a phenotype in these animals—a profound defect in liver regeneration leading to reduced survival after partial hepatectomy. Problems uncovered included changes in lipid metabolism and cell cycle progression. Treating mutant mice with glucose could circumvent the defect and improve survival after liver damage

M. A. Fernández, C. Albor, M. Ingelmo-Torres, S. J. Nixon, C. Ferguson, T. Kurzchalia, F. Tebar, C. Enrich, R. G. Parton, A. Pol, Caveolin-1 is essential for liver regeneration. Science 313, 1628-1632 (2006). [Abstract] [Full Text]

D. L. Brasaemle, A metabolic push to proliferate. Science 313, 1581-1582 (2006). [Summary] [Full Text]