Protein Pathways in Epilepsy

Science's STKE  26 Sep 2006:
Vol. 2006, Issue 354, pp. tw335
DOI: 10.1126/stke.3542006tw335

One cause of epilepsy is mutations in proteins that function in the brain. Fukata et al. identified the partners of a complex of proteins located at rat brain synapses. Of the various components, one (LGI1) seems to function as a ligand, one (ADAM22) as a receptor, and one (PSD-95) as a scaffolding anchor. LGI1 controls the strength of excitatory synapses. Both the ligand and the receptor of this complex are implicated by genetics and mutations as causing certain types of epilepsy.

Y. Fukata, H. Adesnik, T. Iwanaga, D. S. Bredt, R. A. Nicoll, M. Fukata, Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science 313, 1792-1795 (2006). [Abstract] [Full Text]

S. H. Snyder, Adam finds an exciting mate. Science 313, 1744-1745 (2006). [Summary] [Full Text]