03 October 2006
Vol 2006, Issue 355
  • Contents

    • Editorial Guide

    • Perspectives

    • Editors' Choice

      • Staying Young with p16INK4a

        The cyclin-dependent kinase inhibitor p16INK4a appears to play a role in aging-related loss of progenitor cell proliferation and regenerative capacity.

      • Pruning a Dendritic Tree

        Dendritic pruning of ddaC during metamorphosis depends on localized caspase activation.

      • Translating Cues into Action

        Asymmetric localization and translation of β-actin is involved in growth cone turning.

      • TAO2 Directs TAK1 to JNK

        TAO2 prevents TAK1 from activating NF-κB in response to osmotic stress.

      • Stop to Start

        A protein responsible for preventing unwanted immune responses discourages extended liaisons between activated immune cells.

      • Sweet Smell of Communication

        A parasitic plant locates a preferred host by detecting its released odors; disrupting this process could help control parasites of crop plants.

      • Mapping Biological Connectivity

        Comparison of mRNAs evoked by small molecules in human cells to mRNA expressed in diseases and in response to drugs suggests new therapeutic approaches.

      • Muscle Building

        An inherited muscle disease in which certain muscles are weak is caused by mutations in a protein needed for proper formation of the neuromuscular junction.

About The Cover

Cover image expansion

COVER This week's Focus Issue, published to complement the Science Special Issue on genomic evolution, contains an Editorial Guide on how regulatory networks allow genes to control the development of complex organisms as well as three Perspectives illustrating specific examples. The image depicts a Drosophila superimposed on the Wnt signaling pathway. [Image: Christopher Bickel, AAAS]