PerspectiveDevelopment

Gene Control by Large Noncoding RNAs

Science Signaling  03 Oct 2006:
Vol. 2006, Issue 355, pp. pe40
DOI: 10.1126/stke.3552006pe40

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Abstract

Large noncoding RNAs (lncRNAs) have emerged as key players in regulating various fundamental cellular processes. Recent reports identify a functional lncRNA, Evf-2, that operates during development to control the expression of specific homeodomain proteins, and they provide important insights into the mechanism of cooperation between a newly discovered nuclear receptor co-repressor protein (SLIRP) and steroid receptor activator RNA. Evf-2 is the first example of lncRNA directly involved in organogenesis in vertebrates.

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