Channeling Local Translation

Science's STKE  10 Oct 2006:
Vol. 2006, Issue 356, pp. tw348
DOI: 10.1126/stke.3562006tw348

Local, activity-dependent changes in excitability are thought to play a role in various aspects of neuromodulation. Translation of dendritically localized messenger RNAs is one way for a neuron to modify its excitability and signal processing machinery at or near active synapses. Raab-Graham et al. used photoconvertible fluorophores to show that potassium channels are locally translated in dendrites. This local translation is regulated by N-methyl-D-aspartate receptor activation via the mammalian target of rapamycin/phosphatidylinositol 3-kinase signaling pathway.

K. F. Raab-Graham, P. C. G. Haddick, Y. N. Jan, L. Y. Jan, Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314, 144-148 (2006). [Abstract] [Full Text]