Contents
Vol 2006, Issue 357
Contents
Perspectives
- VRACs CARVe a Path for Novel Mechanisms of Communication in the CNS
Astrocyte swelling may trigger glutamate release, thereby influencing neuronal activity.
- Osmosensing by Bacteria
Do different bacterial osmosensors use distinct mechanisms to sense osmotic pressure?
Review
- Regulation and Function of IKK and IKK-Related Kinases
The IκB kinases (IKK) and related enzymes mediate innate immunity and inflammation by regulating gene transcription
Editors' Choice
- Why a Diet Rich in Seafood Is Healthy
Docosahexaenoate (DHA) inhibits activation of NF-κB to prevent COX-2 expression and production of inflammatory prostaglandins.
- Actin Dynamics and Ethanol Sensitivity
Two studies suggest that disruption of mechanisms involved in regulating actin dynamics affects sensitivity to ethanol.
- Innately Malignant?
RalB signaling links innate immune signaling with cancer cell survival.
- No NFAT, No Fat
Animals starved of NFAT transcription factors are resistant to diet-induced obesity.
- Dual Cleavage Events Activate TGF-β
Cleavage by BMP-1-like proteinases followed by cleavage by metalloproteinase releases active TGF-β from the extracellular matrix.
- Not-So-Simple Switches
Multiple untranslated RNA sequences can occur in series upstream of genes to create complex genetic switches regulated by metabolites rather than proteins.
- Dealing with DNA Damage
The death of cells with damaged DNA results in part from altered localization of a transcription factor, triggered by a cell cycle protein.
- Branching Out
Ductal branches in the adult female mammary gland position themselves during development according to the geometry of the precursor epithelial tubule.
- Rethinking Viral Resistance
Although multiple genes are generally thought to control an individual’s resistance to infection, only one gene determines susceptibility to a herpesvirus.
