Regulation and Function of IKK and IKK-Related Kinases

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Science's STKE  17 Oct 2006:
Vol. 2006, Issue 357, pp. re13
DOI: 10.1126/stke.3572006re13

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With six figures and 199 references, this review describes the functions of and regulatory mechanisms controlling the activity of a family of kinases that are instrumental for activation of the host defense system. These kinases are called IKK and IKK-related kinases. The family includes IKKα, IKKβ, and IKKγ, which regulate the activity of the nuclear factor kappa B (NF-κB) family of dimeric transcription factors, and IKKε or IKK-i and one variously named TBK1 (TANK-binding kinase), NAK (NF-κB–activated kinase), or T2K (TRAF2-associated kinase), which regulate the activity of transcription factors that are important for the induction of type I interferon (IFN-I). Through an evaluation of the mechanisms by which NF-κb activity is regulated and the roles that each kinase plays in this process, as well as functions beyond NF-κB regulation, the authors provide insight into the roles these IKKs and related kinases play in immune responses, cell survival, and cancer.