Regulation and Function of IKK and IKK-Related Kinases

+ See all authors and affiliations

Science's STKE  17 Oct 2006:
Vol. 2006, Issue 357, pp. re13
DOI: 10.1126/stke.3572006re13

You are currently viewing the gloss.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


With six figures and 199 references, this review describes the functions of and regulatory mechanisms controlling the activity of a family of kinases that are instrumental for activation of the host defense system. These kinases are called IKK and IKK-related kinases. The family includes IKKα, IKKβ, and IKKγ, which regulate the activity of the nuclear factor kappa B (NF-κB) family of dimeric transcription factors, and IKKε or IKK-i and one variously named TBK1 (TANK-binding kinase), NAK (NF-κB–activated kinase), or T2K (TRAF2-associated kinase), which regulate the activity of transcription factors that are important for the induction of type I interferon (IFN-I). Through an evaluation of the mechanisms by which NF-κb activity is regulated and the roles that each kinase plays in this process, as well as functions beyond NF-κB regulation, the authors provide insight into the roles these IKKs and related kinases play in immune responses, cell survival, and cancer.

Related Content