Editors' ChoiceAging

A Cool Way to a Long Life

Science's STKE  07 Nov 2006:
Vol. 2006, Issue 360, pp. tw383
DOI: 10.1126/stke.3602006tw383

Caloric dietary restriction prolongs life span in a variety of organisms, and in mammals, the resultant lowering of core body temperature has been offered as one potential explanation. Conti et al. generated transgenic mice that overexpress mitochondrial uncoupling protein 2 in hypocretin-producing neurons within the hypothalamus, which lowers core body temperature by about 0.5ºC. In the absence of caloric restriction, the median life span of these "cool mice" was about 15% greater than that of their wild-type littermates.

B. Conti, M. Sanchez-Alavez, R. Winsky-Sommerer, M. C. Morale, J. Lucero, S. Brownell, V. Fabre, S. Huitron-Resendiz, S. Henriksen, E. P. Zorrilla, L. de Lecea, T. Bartfai, Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828 (2006). [Abstract] [Full Text]

C. B. Saper, Life, the universe, and body temperature. Science 314, 773-774 (2006). [Abstract] [Full Text]