Editors' ChoiceCell Biology

Sorting, Signaling, and Sara

Science's STKE  21 Nov 2006:
Vol. 2006, Issue 362, pp. tw399
DOI: 10.1126/stke.3622006tw399

Morphogenic gradients of signaling molecules are key to tissue patterning during development. Endocytic compartments have been shown to play a role in the generation and maintenance of such gradients. Bökel et al. (see the Perspective by Knoblich) now provide evidence that the apical signaling endosome, characterized by the presence of the protein Sara (Smad anchor for receptor activation), uses the mitotic spindle to distribute developmentally important signaling molecules across division. This process ensures that the two daughter cells retain information contained in the morphogen gradient.

C. Bökel, A. Schwabedissen, E. Entchev, O. Renaud, M. González-Gaitán, Sara endosomes and the maintenance of Dpp signaling levels across mitosis. Science 314, 1135-1139 (2006). [Abstract] [Full Text]

J. A. Knoblich, Sara splits the signal. Science 314, 1094-1096 (2006). [Summary] [Full Text]

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