PerspectiveNONCODING RNA

What Is So Special About Oskar Wild?

Science's STKE  12 Dec 2006:
Vol. 2006, Issue 365, pp. pe51
DOI: 10.1126/stke.3652006pe51

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Abstract

The amazing world of regulatory noncoding RNA has been at the center of biologists’ attention in many different fields, from structural biology to transcriptional regulation and cell signaling. The latest example comes from developmental biology. A mutation in the Drosophila gene Oskar reveals a novel developmental function for the 3′ untranslated region (UTR) of the oscar mRNA. This study further suggests that, when transcribed, the noncoding parts of the genome may well carry essential regulatory functions fundamental for the coordinated gene expression and development of multicellular organisms.

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