Making the Gradient

Science's STKE  30 Jan 2007:
Vol. 2007, Issue 371, pp. tw38
DOI: 10.1126/stke.3712007tw38

The role of gradients of morphogens in developmental biology is well established, but the mechanisms involved in the establishment and maintenance of these gradients are controversial. Kicheva et al. present a quantitative study of the kinetics of morphogen transport and the formation of morphogen gradients in the wing disc of Drosophila. The steady-state gradients of two morphogens can be described by a simple exponential decay defined by four key kinetic parameters.

A. Kicheva, P. Pantazis, T. Bollenbach, Y. Kalaidzidis, T. Bittig, F. Jülicher, M. González-Gaitán, Kinetics of morphogen gradient formation. Science 315, 521-525 (2007). [Abstract] [Full Text]