G Protein-Coupled Receptors

Diversifying Role for β-Arrestin

Science's STKE  06 Feb 2007:
Vol. 2007, Issue 372, pp. tw41
DOI: 10.1126/stke.3722007tw41

Intense investigation is focused on understanding mechanisms that control signaling through G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptors (GPCRs), because they are known to be productive targets for therapeutic drugs. Nelson et al. show that β-arrestins, which limit signaling by GPCRs coupled to G proteins of the Gs class, serve a very similar function in control of signaling by M1 muscarinic receptors. The muscarinic receptors use a different class of G protein linked to distinct signaling machinery.

C. D. Nelson, S. J. Perry, D. S. Regier, S. M. Prescott, M. K. Topham, R. J. Lefkowitz, Targeting of diacylglycerol degradation to M1 muscarinic receptors by β-arrestins. Science 315, 663-666 (2007). [Abstract] [Full Text]

E. F. Grady, β-Arrestin, a two-fisted terminator. Science 315, 605-606 (2007). [Summary] [Full Text]