Integrating Cell Signaling Pathways in Development

Science's STKE  13 Feb 2007:
Vol. 2007, Issue 373, pp. tw51
DOI: 10.1126/stke.3732007tw51

During development, signaling by the fibroblast growth factor (FGF) receptor tyrosine kinase enhances mesoderm induction by transforming growth factor-β (TGF-β) and Activin-like growth factors. Cordenonsi et al. combine Xenopus embryology with biochemical analyses to show that FGF signaling promotes phosphorylation of the N-terminal region of the tumor-suppressor protein p53. This modification enables the formation of a complex between p53 and TGF-β-activated Smad, which regulates gene expression and promotes Xenopus mesoderm induction.

M. Cordenonsi, M. Montagner, M. Adorno, L. Zacchigna, G. Martello, A. Mamidi, S. Soligo, S. Dupont, S. Piccolo, Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation. Science 315, 840-843 (2007). [Abstract] [Full Text]