PerspectiveReactive Oxygen Species

Unconventional Roles of the NADPH Oxidase: Signaling, Ion Homeostasis, and Cell Death

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Science's STKE  27 Mar 2007:
Vol. 2007, Issue 379, pp. pe11
DOI: 10.1126/stke.3792007pe11

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Although the central role of the phagocytic NADPH oxidase in mediating bacterial killing has long been appreciated, this sophisticated enzyme complex serves various other important functions. This Perspective focuses on these underappreciated roles of phagocytic NADPH oxidase, highlighting recent work implicating reactive oxygen species in triggering an unconventional form of cell death.

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