PerspectiveDevelopmental Biology

Fat Flies Expanded the Hippo Pathway: A Matter of Size Control

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Science's STKE  03 Apr 2007:
Vol. 2007, Issue 380, pp. pe12
DOI: 10.1126/stke.3802007pe12

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By simultaneously inhibiting cell proliferation while promoting apoptosis, the Hippo signaling pathway provides a robust mechanism to restrict organ size during Drosophila development. Despite impressive progress in revealing the key intracellular components of this growth-regulatory pathway, the nature of the signal that regulates Hippo signaling in vivo has remained elusive. Several studies now implicate the atypical cadherin protein Fat as a cell surface receptor for the Hippo signaling pathway, thus potentially linking the Hippo kinase cascade with the extracellular milieu.

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