PerspectiveProtein Stability

Cdc37 Regulation of the Kinome: When to Hold ‘Em and When to Fold ‘Em

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Science's STKE  08 May 2007:
Vol. 2007, Issue 385, pp. pe22
DOI: 10.1126/stke.3852007pe22

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Although massive genome sequencing efforts have identified the protein kinases encoded by several eukaryotic genomes and proteomic analyses have begun to determine the kinases expressed in a cell, there is still much to learn about the additional cellular events that shape eukaryotic kinomes. Large-scale analyses in Saccharomyces cerevisiae have indicated that a relatively small subset of kinases requires chaperoning by heat shock protein 90 (Hsp90). However, new evidence suggests that most kinases do require chaperoning and, furthermore, that Cdc37, a chaperone that has Hsp90-dependent and -independent functions, serves as the chaperone for a large portion of the yeast kinome.

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